Principal Scientist, ADME/PK

📋 Description

• Lead ADME/PK strategies for pre-targeted therapeutics (biologics & small molecules).
• Define PK/PD and biodistribution strategy to support validation and programs.
• Partner cross-functionally with chemistry, protein engineering, bioanalytical, and tox teams.
• Serve as the PK subject matter expert for pre-targeting systems and click therapeutics.
• Design, analyze, and interpret PK, biodistribution, and mass balance studies.
• Build PK/PD and mechanistic models to predict human dosing.

🎯 Requirements

• PhD in Pharmacokinetics, Pharmaceutical Sciences, Bioengineering, or related field.
• 4+ years of industry ADME/PK leadership on therapeutic programs.
• Deep expertise in PK of biologics and targeted delivery systems.
• Strong experience designing and interpreting in vivo PK and biodistribution studies.
• Demonstrated experience with QSP and PK/PD modeling.
• Experience with modeling tools (Phoenix WinNonlin, NONMEM, Monolix, MATLAB).

🎁 Benefits

• Equity included as part of total compensation.
• Comprehensive benefits: medical, dental, vision, 401(k) match, disability.
• Flexible PTO and a WFH stipend to support remote work.
• Remote-first company with occasional travel for in-person meetings.
• Core collaboration window: 9:00am–3:00pm Pacific Time.
• Growth opportunities, professional development, and mentorship.