Principal Scientist, In Vivo Pharmacology

📋 Description

• Partner with the Director to set the staged in vivo pharmacology plan (target validation and
• Design the CRO-executed rodent and non-human-primate studies (controls, power, pre-specified
• Qualify and manage CRO partners for in vivo studies and outsourced analytics (scope, budget
• Select, qualify, and de-risk the in vivo models, setting performance, variability, and effect-size
• Own the in vivo endpoint suite: quantitative histology and morphometry, tissue-based PD readouts
• With the delivery and analytical chemistry groups, connect biodistribution and tissue exposure to

🎯 Requirements

• PhD in pharmacology, physiology, cell and molecular biology, or a related discipline, with 7+ years
• Demonstrated ownership of in vivo pharmacology workstreams in discovery research and preclinical
• Track record designing, outsourcing, and managing CRO-executed in vivo studies: vendor
• Hands-on rodent experience (dosing by multiple routes, in-life assessment, terminal collection)
• In vivo phenotyping experience (quantitative imaging, histology and morphometry, tissue functional
• Experience developing translational biomarkers across research and development is a plus, as is

🎁 Benefits

• Base salary range at time of posting
• Eligibility for annual bonus
• Eligibility for long-term incentives
• Compensation and benefits may be updated in the future