Research Scientist In Vitro Pharmacology

📋 Description

• Design, optimize, and run functional assays in appropriate cellular liver disease models, selecting
• Evaluate ADAR-mediated RNA editing and siRNA candidates and characterize dose response, durability
• Develop and apply key end points for functional assays (viability assays, ELISA or MSD, and Western
• Interpret results of cell-based functional assays including imaging, protein biomarkers, and
• Use laboratory automation where appropriate to improve assay throughput, reproducibility, and data
• Collaborate across Cambridge and Toronto with program, computational biology, AI and machine

🎯 Requirements

• Ph.D. in cell biology, molecular biology, biochemistry, genetics, gene therapy, immunology, or a
• Biotech or pharmaceutical experience preferred.
• In depth understanding of disease models for liver diseases and hands on experience developing and
• Experience with RNA therapeutics, such as oligonucleotide or mRNA-based approaches, and an
• Experience with foundational functional assay techniques: ELISA, MSD, Western blot or Jess
• Ability to integrate phenotypic data with molecular analyses performed by computational partners.

🎁 Benefits

• A collaborative and innovative environment at the frontier of computational biology, machine
• Highly competitive compensation, including meaningful stock ownership.
• Comprehensive benefits - including health, vision, and dental coverage for employees and families
• Flexible work environment - including flexible hours, extended long weekends, holiday shutdown
• Maternity and parental leave top-up coverage, as well as new parent paid time off.
• Focus on learning and growth for all employees - learning and development budget & lunch and