Senior Research Scientist - Neuroscience

📋 Description

• Lead cellular/tissue target engagement studies for small molecules and PROTACs.
• Develop and scale assays to measure binding, ternary complex formation, and engagement in human systems.
• Build CNS degrader discovery capabilities to inform optimization and translational decisions.
• Collaborate with medicinal chemistry and platform biology to optimize ligands/degraders.
• Analyze, interpret, and integrate datasets across assay platforms to guide decisions.
• Maintain organized results and ELN records for project teams.

🎯 Requirements

• 3+ years in cellular/tissue assays for small molecules and degraders; no visa sponsorship.
• Plate-based assay design, optimization, validation, controls, and artifact identification.
• Experience with probe-based/proximity assays: NanoBRET, TR-FRET, AlphaLISA.
• Adapt assays for robustness, miniaturization, and multi-well formats.
• Strong data analysis skills using Prism, Python, or R.
• Neurodegenerative biology background (tau, alpha-synuclein, TDP-43, Aβ) preferred.

🎁 Benefits

• Competitive base salary and incentive compensation.
• Comprehensive medical, vision, and dental coverage.
• Life insurance and other benefits.