Director, Translational Pharmacokinetics - DMPK

📋 Description

• Lead the design, development, validation, and refinement of PBPK models to characterize drug
• Develop and evolve PKPD models using nonclinical and clinical data to improve predictions of drug
• Generate scientifically robust first-in-human (FIH) dose projections for selected drug candidates
• Integrate in vitro, nonclinical, and clinical pharmacokinetic and pharmacodynamic data into
• Critically evaluate experimental findings, assess model assumptions, and identify additional data
• Conduct simulations to predict potential drug-drug interactions and evaluate how different

🎯 Requirements

• PhD, PharmD, or equivalent advanced scientific degree in pharmacokinetics, pharmaceutical sciences
• At least 12 years of industry experience in pharmacokinetic modeling and simulation, including PBPK
• Extensive hands-on experience developing, validating, and interpreting PBPK and PKPD models, with a
• Experience using pharmacokinetic modeling and simulation platforms such as Simcyp, GastroPlus
• Demonstrated experience supporting IND-enabling programs and regulatory submissions, with the
• Strong analytical skills and the ability to critically evaluate experimental data, assess model

🎁 Benefits

• Annual base salary ranging from $177,000 to $283,800, depending on qualifications, experience
• Eligibility for a company bonus based partly on organizational and individual performance.
• Medical, dental, vision, and prescription drug coverage for eligible employees.
• Access to a company-sponsored 401(k) plan, pension benefits, and flexible spending options for
• Vacation benefits and a range of leave options, subject to applicable company policies.
• Life insurance, death benefits, and additional financial protection options.